Phim ''Vân Trung Ca'' được phát triển dựa trên cuốn tiểu thuyết cùng tên của nhà văn Trung Quốc Đồng Hoa xuất bản vào năm 2007. Cuốn tiểu thuyết này là phần tiếp theo của Đại mạc dao.

''Vân Trung Ca'' lấy bối cảnh thời kỳ Tây Hán, kể về cuộc đời của Vân Ca (Angela Baby), con gái của Hoắc Khứ Bệnh (Vệ Vô Kỵ) và Ngọc Cẩn (Tân Nguyệt) trong Đại Mạc Dao. 

Câu chuyện số mệnh của cô đồng thời gắn liền với hai chàng trai, Lăng ca ca (Lục Nghị) và cậu bé ăn mày Hắn Hồ. Khi tròn 19 tuổi, Vân Ca đã đến Trường An, từ giã tự do nơi sa mạc, bắt đầu chuỗi ngày bất hạnh của chính mình. 

Tại nơi phồn hoa đất khách này, Vân Ca gặp gỡ Lăng ca ca – Hán Chiêu Đế, người khiến cô cuốn vào cuộc tranh giành quyền lực đầy “âm mưu” ở chốn cung đình.

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